We've chosen the Age Hack's NAD+ as it is a cofactor found in all living cells. NAD+ is an important carrier of electrons and hydrogen for the cell and is crucial for the ongoing production of energy by the mitochondria. NAD+ helps to fuel over 400 metabolic reactions. It has been demonstrated that NAD+ availability decreases over age, reducing sirtuin activities and affecting the communication between the nucleus and mitochondria at a cellular level and also between the hypothalamus and adipose tissue at a systemic level. These dynamic cellular and systemic processes likely contribute to the development of age-associated functional decline and the pathogenesis of diseases of aging.